| 1 | MIAMiamiInter Miami CFShield | 34 | 22 | 4 | 8 | 79 | 49 | +30 | 74 | 2.18 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 2 | CLBColumbusColumbus Crew | 34 | 19 | 6 | 9 | 72 | 40 | +32 | 66 | 1.94 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 3 | LAFCLAFCLos Angeles FC | 34 | 19 | 8 | 7 | 63 | 43 | +20 | 64 | 1.88 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 4 | LALA GalaxyLA GalaxyMLS Cup | 34 | 19 | 8 | 7 | 69 | 50 | +19 | 64 | 1.88 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 5 | CINCincinnatiFC Cincinnati | 34 | 18 | 11 | 5 | 58 | 48 | +10 | 59 | 1.74 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 6 | RSLSalt LakeReal Salt Lake | 34 | 16 | 7 | 11 | 65 | 48 | +17 | 59 | 1.74 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 7 | SEASeattleSeattle Sounders FC | 34 | 16 | 9 | 9 | 51 | 35 | +16 | 57 | 1.68 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 8 | HOUHoustonHouston Dynamo FC | 34 | 15 | 10 | 9 | 47 | 39 | +8 | 54 | 1.59 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 9 | ORLOrlandoOrlando City SC | 34 | 15 | 12 | 7 | 59 | 50 | +9 | 52 | 1.53 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 10 | MINMinnesotaMinnesota United FC | 34 | 15 | 12 | 7 | 58 | 49 | +9 | 52 | 1.53 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 11 | CLTCharlotteCharlotte FC | 34 | 14 | 11 | 9 | 46 | 37 | +9 | 51 | 1.50 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 12 | COLColoradoColorado Rapids | 34 | 15 | 14 | 5 | 61 | 60 | +1 | 50 | 1.47 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 13 | NYCNYCFCNew York City FC | 34 | 14 | 12 | 8 | 54 | 49 | +5 | 50 | 1.47 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 14 | VANVancouverVancouver Whitecaps FC | 34 | 13 | 13 | 8 | 52 | 49 | +3 | 47 | 1.38 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 15 | PORPortlandPortland Timbers | 34 | 12 | 11 | 11 | 65 | 56 | +9 | 47 | 1.38 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 16 | RBNYRed BullsNew York Red BullsFinalist | 34 | 11 | 9 | 14 | 55 | 50 | +5 | 47 | 1.38 | Qualifies for MLS Cup Playoffs - Round One Best-of-3 series |
| 17 | MTLMontréalCF Montréal | 34 | 11 | 13 | 10 | 48 | 64 | −16 | 43 | 1.26 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 18 | ATXAustinAustin FC | 34 | 11 | 14 | 9 | 39 | 48 | −9 | 42 | 1.24 | |
| 19 | DALDallasFC Dallas | 34 | 11 | 15 | 8 | 54 | 56 | −2 | 41 | 1.21 | |
| 20 | ATLAtlantaAtlanta United FC | 34 | 10 | 14 | 10 | 46 | 49 | −3 | 40 | 1.18 | Qualifies for MLS Cup Playoffs - Wild Card Matches |
| 21 | DCD.C.D.C. United | 34 | 10 | 14 | 10 | 52 | 70 | −18 | 40 | 1.18 | |
| 22 | TORTorontoToronto FC | 34 | 11 | 19 | 4 | 40 | 61 | −21 | 37 | 1.09 | |
| 23 | PHIPhiladelphiaPhiladelphia Union | 34 | 9 | 15 | 10 | 62 | 55 | +7 | 37 | 1.09 | |
| 24 | STLSt. LouisSt. Louis City SC | 34 | 8 | 13 | 13 | 50 | 63 | −13 | 37 | 1.09 | |
| 25 | NSHNashvilleNashville SC | 34 | 9 | 16 | 9 | 38 | 54 | −16 | 36 | 1.06 | |
| 26 | NENew EnglandNew England Revolution | 34 | 9 | 21 | 4 | 37 | 74 | −37 | 31 | 0.91 | |
| 27 | SKCSporting KCSporting Kansas City | 34 | 8 | 19 | 7 | 51 | 66 | −15 | 31 | 0.91 | |
| 28 | CHIChicagoChicago Fire FC | 34 | 7 | 18 | 9 | 40 | 62 | −22 | 30 | 0.88 | |
| 29 | SJSan JoseSan Jose EarthquakesSpoon | 34 | 6 | 25 | 3 | 41 | 78 | −37 | 21 | 0.62 | |